Bioactividad de polisacáridos de trametes versicolor en el tratamiento de pacientes con cáncer. Una revisión sistemática de la literatura

Francisco Andrés Torres Vinueza; Carem Francelys  Prieto Fuenmayor

Bioactividad de polisacáridos de trametes versicolor en el tratamiento de pacientes con cáncer. Una revisión sistemática de la literatura

Autores/as

Francisco Andrés Torres Vinueza Universidad Católica de Cuenca
Carem Francelys Prieto Fuenmayor Universidad Católica de Cuenca

Palabras clave:

Cáncer, β-glucano, Inmunomodulación, Neoplasia, Polisacáridos, Polisacárido-K, Trametes Versicolor

Resumen

En el estudio sobre la bioactividad de polisacáridos en el tratamiento de pacientes con cáncer, se abordó el potencial terapéutico del hongo Trametes Versicolor. El presente artículo tenía como objetivo principal analizar los efectos curativos para el tratamiento y control de la sintomatología propia del cáncer en sus diversas tipologías. Para ello, se ejecutó una revisión sistemática de la literatura científica publicada entre los años 2000 y 2023 a través de la metodología PRISMA, la misma que involucró la búsqueda de documentos en diversos gestores bibliográficos en base a los criterios de inclusión y exclusión de información. Los materiales y métodos empleados para la revisión literaria incluyen bases de datos como NCBI Pubmed, Scopus y Web of Science además, se utilizó términos booleanos o palabras clave las cuales tenían relación con el tema de estudio para seleccionar artículos que abordaran de manera específica el tratamiento del cáncer con derivados de Trametes Versicolor. Los resultados obtenidos revelaron que los polisacáridos de Trametes Versicolor mostraron una notable actividad anticancerígena, con capacidad para inhibir la proliferación celular y promover la apoptosis en diferentes tipos de cáncer. Como conclusión del artículo, se presenta que Trametes Versicolor al ser una medicina ancestral proveniente de Japón podría representar una opción terapéutica prometedora en el tratamiento de los distintos tipos de cáncer, ofreciendo una alternativa natural y efectiva que permite mejorar la calidad de vida de los pacientes a la par que reduce la incidencia de los efectos secundarios propios de la quimioterapia y radioterapia.

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Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May 4;71(3):209–49. https://doi.org/10.3322/caac.21660

He Y, Liu S, Newburg DS. Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth. Biomedicine & Pharmacotherapy. 2021 Dec;144. https://doi.org/10.1016/j.biopha.2021.112339

Fisher M, Yang LX. Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy. Anticancer Res. 2002;22(3):1737–54.

Ricciardi M, Licchetta R, Mirabilii S, Scarpari M, Parroni A, Fabbri AA, et al. Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite. Oxid Med Cell Longev. 2017;2017:1–8. https://doi.org/10.1155/2017/5061639

Jiménez E, Berruguilla E, Romero I, Algarra I, Collado A, Garrido F, et al. The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer. 2008 Dec 24;8(1):78. https://doi.org/10.1186/1471-2407-8-78

Harhaji Lj, Mijatović S, Maksimović D, Stojanović I, Momčilović M, Maksimović V, et al. Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study. Food and Chemical Toxicology. 2008 May;46(5):1825–33. https://doi.org/10.1016/j.fct.2008.01.027

Hsieh T chen, Wu P, Park S, Wu JM. Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I’m-YunityTM (PSP). BMC Complement Altern Med. 2006 Dec 11;6(1):30. https://doi.org/10.3892/ijo.18.1.81

Wang D feng, Lou N, Li X dong. Effect of Coriolus Versicolor Polysaccharide-B on the Biological Characteristics of Human Esophageal Carcinoma Cell Line Eca109. Cancer Biol Med. 2012;9(3):164–7.

Hirahara N, Edamatsu T, Fujieda A, Fujioka M, Wada T, Tajima Y. Protein-bound polysaccharide-K induces apoptosis via mitochondria and p38 mitogen-activated protein kinase-dependent pathways in HL-60 promyelomonocytic leukemia cells. Oncol Rep. 2013 Jul;30(1):99–104.

Hirahara N, Fujioka M, Edamatsu T, Fujieda A, Sekine F, Wada T, et al. Protein-bound polysaccharide-K (PSK) induces apoptosis and inhibits proliferation of promyelomonocytic leukemia HL-60 cells. Anticancer Res. 2011;31(9):2733–8. https://doi.org/10.3892/or.2013.2412

Hirahara N, Edamatsu T, Fujieda A, Fujioka M, Wada T, Tajima Y. Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells. Anticancer Res. 2012;32(7):2631–7.

Yang X, Sit WH, Chan D, Wan J. The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells. Oncol Rep. 2005 Jun 1;13(6):1201–10. https://doi.org/10.3892/or.13.6.1201

Wan J, Sit WH, Louie J. Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol. 2008 Mar 1;32(3):689–99. https://doi.org/10.3892/ijo.32.3.689

Ho C, Kim C, Leung K, Fung K, Tse T, Chan H, et al. Coriolus versicolor (Yunzhi) extract attenuates growth of human leukemia xenografts and induces apoptosis through the mitochondrial pathway. Oncol Rep. 2006;16(3):609–16.

Chauhan P, Kumarasamy M, Sosnik A, Danino D. Enhanced Thermostability and Anticancer Activity in Breast Cancer Cells of Laccase Immobilized on Pluronic-Stabilized Nanoparticles. ACS Appl Mater Interfaces. 2019 Oct 30;11(43):39436–48. https://doi.org/10.1021/acsami.9b11877

Jiang J, Thyagarajan A, Loganathan J, Eliaz I, Terry C, Sandusky G, et al. BreastDefendTM prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncol Rep. 2012 Oct;28(4):1139–45. https://doi.org/10.3892/or.2012.1936

Ko CH, Yue GGL, Gao S, Luo KW, Siu WS, Shum WT, et al. Evaluation of the combined use of metronomic zoledronic acid and Coriolus versicolor in intratibial breast cancer mouse model. J Ethnopharmacol. 2017 May;204:77–85. https://doi.org/10.1016/j.jep.2017.04.007

Ho JCK, Konerding MA, Gaumann A, Groth M, Liu WK. Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Life Sci. 2004 Jul;75(11):1343–56. https://doi.org/10.1016/j.lfs.2004.02.021

Coles M, Toth B. Lack of prevention of large intestinal cancer by VPS, an extract of Coriolus versicolor mushroom. In Vivo. 2005 Jan 25;19(5):867–71. https://doi.org/10.1080/10915810601163939

Wenner C, Martzen M, Lu H, Verneris M, Wang H, Slaton J. Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer. Int J Oncol. 2012 Apr;40(4):905–13. https://doi.org/10.3892/ijo.2011.1292

Fujii T, Saito K, Matsunaga K, Oguchi Y, Ikuzawa M, Furusho T, et al. Prolongation of the survival period with the biological response modifier PSK in rats bearing N-methyl-N-nitrosourea-induced mammary gland tumors. In Vivo. 1995;9(1):55–7.

Shnyreva A, Shnyreva A, Espinoza C, Padrón JM, Trigos Á. Antiproliferative Activity and Cytotoxicity of Some Medicinal Wood-Destroying Mushrooms from Russia. Int J Med Mushrooms. 2018;20(1):1–11. https://doi.org/10.1615/IntJMedMushrooms.2018025250

Ho CY, Kim CF, Leung KN, Kwok-Pui F, Tse TF, Chan H, et al. Differential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells. Cancer Biol Ther. 2005 Jun 27;4(6):638–44. 638–644. https://doi.org/10.4161/cbt.4.6.1721

Aoyagi H, lino Y, Takeo T, Horii Y, Morishita Y, Horiuchi R. Effects of OK-432 (Picibanil) on the Estrogen Receptors of MCF-7 Cells and Potentiation of Antiproliferative Effects of Tamoxifen in Combination with OK-432. Oncology. 1997;54(5):414–23. https://doi.org/10.1159/000227728

Kobayashi Y, Kariya K, Saigenji K, Nakamura K. Enhancement of anti-cancer activity of cisdiaminedichloroplatinum by the protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) in vitro. Cancer Biother. 1994 Jan;9(4):351–8. https://doi.org/10.1089/cbr.1994.9.351

Knežević A, Stajić M, Sofrenić I, Stanojković T, Milovanović I, Tešević V, et al. Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia. PLoS One. 2018 Aug 31;13(8). https://doi.org/10.1371/journal.pone.0203064

Pawlikowska M, Piotrowski J, Jędrzejewski T, Kozak W, Slominski AT, Brożyna AA. Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells. Phytotherapy Research. 2020 Jan 12;34(1):173–83. https://doi.org/10.1002/ptr.6513

Roca D, Martinez O, Portela C, Rodríguez A, Valladares M, Díaz A, et al. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells. Int J Med Sci. 2019;16(2):231–40. https://doi.org/10.7150/ijms.28811

Luo KW, Yue GGL, Ko CH, Lee JKM, Gao S, Li LF, et al. In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine. 2014 Jul;21(8–9):1078–87. https://doi.org/10.1016/j.phymed.2014.04.020

Yang MMP, Chen Z, Kwok JSL. The Anti-tumor Effect of a Small Polypeptide from Coriolus versicolor (SPCV). Am J Chin Med (Gard City N Y). 1992 Jan 30;20((3-4)):221–32. https://doi.org/10.1142/S0192415X92000230

Hui K, Sit W, Wan J. Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells. Oncol Rep. 2005;14(1):145–455.

Zeng F, Hon CC, Sit WH, Chow K, Hui R, Law I, et al. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. Int J Oncol. 2005 Aug 1;27(2):513–23. https://doi.org/10.3892/ijo.27.2.513

Wan J, Sit WH, Yang X, Jiang P, Wong LLY. Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells. Chin Med. 2010;5(1):16. https://doi.org/10.1186/1749-8546-5-16

Kim F, Sakagami H, Tanuma S, Konno K. Stimulation of interferon-gamma-induced human myelogenous leukemic cell differentiation by high molecular weight PSK subfraction. Anticancer Res. 1990;10(1):55–8.

Hsieh TC, Wu JM. Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells. Int J Oncol. 2001 Jan 1;18(1):81–8. https://doi.org/10.1186/1472-6882-6-30

Luk SU, Lee TKW, Liu J, Lee DTW, Chiu YT, Ma S, et al. Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population. PLoS One. 2011 May 16;6(5). https://doi.org/10.1371/journal.pone.0019804

Mao XW, Green LM, Gridley DS. Evaluation of Polysaccharopeptide Effects against C6 Glioma in Combination with Radiation. Oncology. 2001;61(3):243–53. https://doi.org/10.1159/000055381

Dong Y, Kwan C, Chen Z, Yang M. Antitumor effects of a refined polysaccharide peptide fraction isolated from Coriolus versicolor: in vitro and in vivo studies. Res Commun Mol Pathol Pharmacol. 1996;92(2):140–8.

Kobayashi Y, Kariya K, Saigenji K, Nakamura K. Suppression of Cancer Cell Growth In Vitro by the Protein-Bound Polysaccharide of Coriolus versicolor QUEL (PS-K) with SOD Mimicking Activity. Cancer Biother. 1994 Jan;9(1):63–9. https://doi.org/10.1089/cbr.1994.9.63

Gu T, Li G, Wu X, Zeng T, Xu Q, Li L, et al. Effects of immunopotentiators on biochemical parameters, proinflammatory cytokine, and nonspecific immune responses in Shaoxing ducklings. . Poult Sci. 2020;99(11):5461–71.

Kohgo Y, Hirayama Y, Sakamaki S, Matsunaga T, Ohi S, Kuga T, et al. Improved Recovery of Myelosuppression following Chemotherapy in Mice by Combined Administration of PSK and Various Cytokines. Acta Haematol. 1994;92(3):130–5. https://doi.org/10.1159/000204202

Fujii T, Kano T, Saito K, Kobayashi Y, Iijima H, Matsumoto T, et al. Effect of PSK on prohibited immunity of splenectomized mice. Anticancer Res. 1987;7(4):845–8.

Matsunaga K, Morita I, Oguchi Y, Fujii T, Yoshikumi C, Nomoto K. Gan to kagaku ryoho. Cancer & chemotherapy. Cancer & chemotherapy. 1986;13(12):3468–75.

Matsunaga K, Matsunaga K, Oguchi Y, Oguchi Y, Yoshikumi C, Nomoto K. Restoration of immune responsiveness by a biological response modifier, PSK, in aged mice bearing syngeneic transplantable tumor. J Clin Lab Immunol. 1987;24(3):143–9.

Hattori T, Hamai Y ichiroh, Ikeda T, Takiyama W, Hirai T, Miyoshi Y. Survival time of tumor-bearing rats as related to operative stress and immunopotentiators. Jpn J Surg. 1982 Mar;12(2):143–147. https://doi.org/10.1007/BF02469383

Mayer P, Drews J. The effect of a protein-bound polysaccharide from coriolus versicolor on immunological parameters and experimental infections in mice. Infection. 1980 Jan;8(1):13–21. https://doi.org/10.1007/BF01677393

Li X, Wang J, Zhu P, Liu L, Ge J, Yang S. Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor. Zhongguo yao li xue bao. 1990;11(6):542–5.

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009 Jul 21;6(7). https://doi.org/10.1371/journal.pmed.1000097

Chay WY, Tham CK, Toh HC, Lim HY, Tan CK, Lim C, et al. Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy. The Journal of Alternative and Complementary Medicine. 2017 Aug;23(8):648–52.

Tsang K, Lam C, Yan C, Mak J, Ooi G, Ho J, et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Respir Med. 2003 Jun;97(6):618–24. https://doi.org/10.1053/rmed.2003.1490

Sakai T, Yamashita Y, Maekawa T, Mikami K, Hoshino S, Shirakusa T. Immunochemotherapy with PSK and Fluoropyrimidines Improves Long-Term Prognosis for Curatively Resected Colorectal Cancer. Cancer Biother Radiopharm. 2008 Aug;23(4):461–8. https://doi.org/10.1089/cbr.2008.0484

Ito G, Tanaka H, Ohira M, Yoshii M, Muguruma K, Kubo N, et al. Correlation between efficacy of PSK postoperative adjuvant immunochemotherapy for gastric cancer and expression of MHC class I. Exp Ther Med. 2012 Jun;3(6):925–30. https://doi.org/10.3892/etm.2012.537

Torkelson C, Sweet E, Martzen M, Sasagawa M, Wenner C, Gay J, et al. Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012 May 30;2012:1–7. https://doi.org/10.5402/2012/251632

Ramasubbu SK, Pasricha RK, Nath UK, Rawat VS, Das B. Quality of life and factors affecting it in adult cancer patients undergoing cancer chemotherapy in a tertiary care hospital. Cancer Rep. 2021;4(2). https://doi.org/10.1002/cnr2.1312

Habtemariam S. Polysaccharides in Cancer Therapy : Targets and Efficacy. Biomedicines. 2020;8(135):26. https://doi.org/https://doi.org/10.3390/biomedicines8050135

Rivera M, Leon E. Delays in Breast Cancer Detection and Treatment in Developing Countries. Breast Cancer (Auckl). 2018 Jan 1;12:1–5. https://doi.org/10.1177/1178223417752677

He Z, Lin J, He Y, Liu S. Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment. Biomedicines. 2022;10(11).

He Y, Liu S, Newburg DS. Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth. Biomedicine & Pharmacotherapy. 2021 Dec;144. https://doi.org/10.1016/j.biopha.2021.112339

Lowenthal R, Taylor M, Gidden JA, Heflin B, Lay JO, Avaritt N, et al. The mycelium of the Trametes versicolor synn. Coriolus versicolor (Turkey tail mushroom) exhibit anti-melanoma activity in vitro. Biomedicine & Pharmacotherapy. 2023 May;161. https://doi.org/10.1016/j.biopha.2023.114424

Jian L, Zhicheng H. Polysaccharide peptide induced colorectal cancer cells apoptosis by down-regulating EGFR and PD-L1 expression. Iran J Pharm Res. 2022;21(1).